Methylcobalamin (B-12) plays an important role in the formation of red blood cells in the functioning of the brain and nervous system and in the regulation of the immune system.
Cobalamin deficiency can cause megaloblastic anemia peripheral neuropathy irritability dementia depression psychosis increased risk of myocardial infarction and occurrence of stroke.
Evidence suggests that methylcobalamin has metabolic benefits and potential therapeutic applications not offered by other forms of vitamin B-12. Although cyanocobalamin is the most common form of vitamin B-12 in supplements it must be converted to methylcobalamin or adenosylcobalamin. Nutritional deficiencies enzyme defects and tissue abnormalities can reduce the body's ability to synthesize these active forms.
Methylcobalamin participates in the synthesis of methionine from homocysteine. This contributes to the reduction of homocysteine levels which is recognized as a risk factor for cardiovascular disease. It is also important for the formation of the neurotransmitters dopamine and serotonin.
The biologically active form of NOW Methyl B12 is a powerful methyl group donor to the myelin sheath that insulates nerve fibers and regenerates damaged neurons. Recent evidence suggests that methylcobalamin may be beneficial for patients with neuropathies.