Berberine & White Mulberry Extract (DNJ) – Benefits on Sugar, LDL, Insulin Resistance & Obesity
Berberine: A natural alkaloid found in plants of the Berberis genus.
Mechanism: Activates AMPK (an enzyme complex, a kinase), increases the expression of insulin receptor and LDL receptors in the liver, reduces glucose production and carbohydrate absorption in the intestine.
- Improves glycemic control
- Reduces insulin resistance
- Reduces total cholesterol
- Reduces LDL cholesterol
- Reduces triglycerides
- Reduces body weight
- Reduces adipose tissue
1-Deoxynojirimycin (DNJ): A natural alkaloid found in the leaves of white mulberry (Morus alba).
Mechanism: The leaves contain the active ingredient 1-Deoxynojirimycin (DNJ), an alpha-glucosidase inhibitor that slows down digestion and carbohydrate absorption. This enzyme mainly breaks down complex carbohydrates (starch – polysaccharides) into simpler sugars, which are then absorbed as glucose. It is traditionally used to control postprandial sugar.
- Reduces postprandial hyperglycemia
- Reduces total cholesterol
- Reduces LDL cholesterol
- Reduces triglycerides
- Reduces body weight
- Reduces adipose tissue
In conclusion, both berberine and white mulberry extract are promising natural interventions for improving insulin resistance, glycemia, LDL cholesterol, and for managing obesity always as part of a holistic plan that includes balanced diet and exercise. Their selection and dosage should be carefully made based on available scientific data and under supervision for optimal results.
23 
