The Solgar Folate is a dietary supplement in tablets, with 400μg of folic acid per tablet in the Metafolin® form, i.e. as L-methylfolate calcium. The amount corresponds to 200% of the Reference Dietary Intakes. The package contains 50 tablets. Note that the listing name mentions 400mg, while the actual content per tablet is 400μg, as stated by the manufacturer.
It is aimed at adults who want daily intake of folic acid in a form that does not require enzymatic conversion, women of reproductive age who have discussed folic acid intake with their doctor, and those who follow a diet low in leafy green vegetables, legumes, and liver, the main dietary sources of the vitamin.
Folic acid is not used by the body as we get it. In its synthetic form, folic acid must undergo successive enzymatic steps until it reaches 5-methyltetrahydrofolate, the form that actually circulates in the blood and enters cells. The last of these steps is carried out by an enzyme called methylenetetrahydrofolate reductase, known by the initials MTHFR.
The reason this pathway matters is that 5-methyltetrahydrofolate is the methyl group donor that converts homocysteine to methionine. From there, S-adenosylmethionine is produced, the central molecule of cellular methylation, which participates in DNA synthesis, gene regulation, and neurotransmitter metabolism. At the same time, folic acid is essential for the synthesis of purines and thymidine, the structural components of DNA, which explains why tissues with rapid cell division, such as bone marrow, are the first to be affected when it is lacking. The Metafolin® form bypasses the enzymatic steps, as it is already the final product.
According to Solgar's product presentation, the formulation is described as follows:
The above statements are attributed to the producer. The reference to MTHFR polymorphism and the comparative use of the methylated form do not correspond to an approved health claim and remain the subject of research.
The composition is mono-ingredient and folic acid has approved health claims. With 400μg per tablet, i.e. twice the Reference Dietary Intakes, the dose comfortably covers the significance threshold for each of them:
The form used is L-methylfolate calcium, patented as Metafolin®. The tablet is suitable for vegans and is Kosher certified.
It suits women of reproductive age who have discussed folic acid intake with their gynecologist and want a mono-ingredient formulation with a clear dose. It suits those who have been informed by their doctor of MTHFR polymorphism and prefer the methylated form. It suits individuals with limited consumption of green leafy vegetables and legumes. Finally, it suits vegans who check the composition of each supplement, as the formula contains no ingredients of animal origin.
The product is a dietary supplement and does not replace medical diagnosis or treatment or prenatal care. The dose of folic acid in pregnancy is determined by the attending physician.
Main ingredients: per 1 tablet, folic acid (as L-methylfolate calcium, Metafolin®) 400μg (200% RDI). RDI: Reference Dietary Intakes in the EU.
Other ingredients: mannitol, microcrystalline cellulose, vegetable stearic acid, silicon dioxide, vegetable stearate magnesium, gum cellulose with crosslinks.
Free from: sugar, starch, gluten, yeast, wheat, soy, dairy, preservatives, artificial flavors or colors. Vegan and Kosher.
Form: tablets.
Recommended dosage: taken as a dietary supplement for adults, 1 (one) tablet daily, preferably with a meal.
With one tablet a day, the package of 50 tablets covers approximately seven weeks of continuous use. Do not exceed the recommended daily dose. Excessive consumption may have a laxative effect due to the mannitol. Dietary supplements should not be used as a substitute for a balanced diet.
In case of pregnancy, breastfeeding, pregnancy planning, or taking medication, consult a doctor or pharmacist before use. Special care is needed in treatment with methotrexate or anticonvulsants, and in individuals with possible vitamin B12 deficiency, as high folic acid intake may mask hematological findings of deficiency. Keep the product in a cool and dry place, away from children.
It is L-methylfolate calcium, i.e. the form in which folic acid ends up after its metabolic processing. It is taken ready, without needing conversion.
Each tablet contains 400μg, an amount corresponding to 200% of the Reference Dietary Intakes.
This is a typographical inconsistency of the listing. The declared content by the manufacturer is 400μg per tablet, i.e. micrograms.
It is a common genetic variation of the enzyme that converts folic acid to its active form. Its detection is done only with laboratory testing and its interpretation is up to the doctor.
With one tablet a day, the 50 tablets last for about seven weeks.
Folic acid and B12 work in the same metabolic pathway. If you are taking high doses of folic acid, discuss B12 level checks with your doctor.
Yes. The formula contains no ingredients of animal origin and is also Kosher certified.
The instruction is one tablet daily with a meal. The time does not matter much, as long as it is consistent.
* Health claims approved under Regulation (EC) 1924/2006. The product is not intended for the prevention, treatment or diagnosis of a human disease.
Nestlé Hellas SA
Patroklou 4, 15125 Marousi, Athens
Tel: 800 116 80 68
Main ingredients: per 1 tablet, folic acid (as L-methylfolate calcium, Metafolin®) 400μg (200% RDI). RDI: Reference Dietary Intakes in the EU.
Other ingredients: mannitol, microcrystalline cellulose, vegetable stearic acid, silicon dioxide, vegetable stearate magnesium, gum cellulose with crosslinks.
Free from: sugar, starch, gluten, yeast, wheat, soy, dairy, preservatives, artificial flavors or colors. Vegan and Kosher.
Form: tablets.
Recommended dosage: taken as a dietary supplement for adults, one (1) tablet daily, preferably with a meal.
With one tablet per day, the 50 tablet pack covers approximately seven weeks of continuous use. Do not exceed the recommended daily dose. Excessive consumption may have a laxative effect due to the mannitol. Dietary supplements should not be used as a substitute for a balanced diet.
In case of pregnancy, breastfeeding, pregnancy planning, or taking medication, consult a doctor or pharmacist before use. Special care is needed in treatment with methotrexate or antiepileptics, and in people with possible vitamin B12 deficiency, as high folic acid intake may mask hematological findings of deficiency. Keep the product in a cool and dry place, away from children.
