The Solgar Homocysteine Modulators is a dietary supplement in plant capsules, from the Gold Specifics range. Each plant capsule provides 500mg trimethylglycine, 28mg vitamin B6 (as pyridoxine hydrochloride and pyridoxal-5-phosphate), 250µg vitamin B12 as cyanocobalamin and 200µg folic acid. The package contains 60 plant capsules and the dosage is one capsule per day.
It is aimed at adults who monitor their homocysteine metabolism with their doctor and want a targeted intake of the three B vitamins involved in it. It is also an option for vegans, who get no vitamin B12 from their diet.
Homocysteine is an amino acid not obtained from the diet but produced in the body as an intermediate product of methionine metabolism, an essential amino acid found in proteins. The body has two main ways to manage it. One is remethylation, i.e. converting it back to methionine, and the other is sulfuration, i.e. converting it to cysteine.
Both pathways depend on specific nutrients. Folic acid and vitamin B12 function in remethylation, vitamin B6 in the pathway to cysteine, and trimethylglycine, also known as betaine, is a methyl donor and an alternative remethylation pathway. That is why Solgar combines them in the same capsule. Folic acid, vitamin B6 and vitamin B12 contribute to the normal metabolism of homocysteine, and this is an approved health claim.*
According to the product presentation by Solgar, the formula is associated with the following points:
The above statements are attributed to the producer. Trimethylglycine does not have an approved health claim by EFSA and remains a subject of research. From the producer's presentation, no connection is made between homocysteine and heart health, as this is a disease risk reduction claim not allowed for dietary supplements.
It suits adults who regularly monitor their tests and want a targeted intake of folate, B6 and B12 in one capsule. It suits vegans and strict vegetarians, as vitamin B12 is not present in plant foods. It suits older people, in whom the absorption of B12 from food often becomes less effective. It also suits those who prefer a specialized formula instead of a general multivitamin.
Solgar Homocysteine Modulators is a dietary supplement. It does not replace a medical diagnosis, monitoring or treatment, and is not intended to prevent, treat or cure human disease. Elevated homocysteine levels in a blood test should always be evaluated by a doctor.
Main ingredients per plant capsule: Trimethylglycine 500mg, Vitamin B6 (as pyridoxine hydrochloride and as pyridoxal-5-phosphate) 28mg (2000% DV), Vitamin B12 (as cyanocobalamin) 250µg (10000% DV), Folic acid (as pteroylmonoglutamic acid) 200µg (100% DV).
Other ingredients: Plant capsule shell (hydroxypropylmethylcellulose), anti-caking agents (vegetable stearic acid, vegetable stearic magnesium), bulking agents (microcrystalline cellulose, mannitol), antioxidant Phyto X.
Free from: sugar, salt, yeast, wheat, soy, gluten, dairy, lactose, preservatives, artificial flavors or colors. Vegan and Kosher.
Form: plant capsules
Recommended dosage: for adults, one plant capsule per day, preferably with a meal.
With 60 plant capsules per package and one capsule per day, the package covers 60 days, i.e. two months of use. Do not exceed the recommended daily dosage. Dietary supplements should not be used as a substitute for a balanced diet.
The producer notes that long-term intake of this amount of vitamin B6 may cause tingling or numbness, so the duration of use is worth discussing with a doctor or pharmacist. If you are pregnant or breastfeeding, if you are on medication or if you have a health condition, seek their advice before use. Keep the product in a cool and dry place, away from children.
It is betaine, a compound naturally found in beets and grains and acts as a methyl donor in metabolism.
One plant capsule per day, preferably with a meal, without exceeding this dose.
The formula is targeted at the metabolism of homocysteine. That is why the producer warns against long-term intake and recommends medical guidance.
Yes. The product carries vegan labeling, with a plant capsule shell and plant extracts.
Homocysteine levels are measured with a blood test. The assessment and recommendation are up to your doctor.
No. The formula is limited to trimethylglycine, B6, B12 and folic acid, without metals.
Calculate the total daily intake of B6, as it is already high here, and discuss the combination with your pharmacist.
Sixty days, i.e. two months, with one capsule per day.
* Health claims approved under Regulation (EC) 1924/2006. The product is not intended to prevent, treat or cure human disease.
Nestlé Greece SA
Patroklou 4, 15125 Marousi, Athens
Tel: 800 116 80 68
Main ingredients per phytocapsule: Trimethylglycine 500mg, Vitamin B6 (as pyridoxine hydrochloride and as pyridoxal-5′-phosphate) 28mg (2000% DV), Vitamin B12 (as cyanocobalamin) 250μg (10000% DV), Folic acid (as pteroylmonoglutamic acid) 200μg (100% DV).
Other ingredients: Phytocapsule coating (hydroxypropyl methylcellulose), anti-caking agents (vegetable stearic acid, vegetable stearic magnesium), bulking agents (microcrystalline cellulose, mannitol), antioxidant Phyto X.
Free from: sugar, salt, yeast, wheat, soy, gluten, dairy, lactose, preservatives, artificial flavors or colors. Vegan and Kosher.
Form: vegetable capsules
Recommended dosage: for adults, one phytocapsule daily, preferably with meal.
With 60 phytocapsules per package and one capsule daily, the package covers 60 days, i.e., two months of use. Do not exceed the recommended daily dose. Dietary supplements should not be used as a substitute for a balanced diet.
The manufacturer indicates that long-term intake of this amount of vitamin B6 may cause tingling or numbness, so the duration of use is worth discussing with a doctor or pharmacist. If you are pregnant or breastfeeding, if you are on medication or if you have a health problem, seek their advice before use. Keep the product in a cool and dry place, away from children.
